Compounds and methods of use thereof

Details Compounds and methods of use thereof Compounds and methods of use thereof

C - Chemistry, Metallurgy

07

F

C07F 5/02 (2006.01) A61K 31/4184 (2006.01) A61K 31/427 (2006.01) A61K 31/437 (2006.01) A61K 31/69 (2006.01) C07D 235/18 (2006.01) C07D 417/04 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2585766

Imidazole and benzimidazole boronic acid compounds, analogs thereof, and pharmaceutical formulations are described, along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF- .alpha.) in a subject in need thereof.

L'invention concerne des composés d'acide boronique d'imidazole et de benzimidazole, des analogues de ces composés et des formulations pharmaceutiques, ainsi que des méthodes d'utilisation de ces composés pour inhiber des cytokines inflammatoires, telles que le facteur de nécrose tumorale alpha (TNF-.alpha.), chez un sujet nécessitant un traitement.

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