C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/42 (2006.01) C08L 91/00 (2006.01) C12N 9/16 (2006.01) C12Q 1/34 (2006.01) G01N 21/76 (2006.01) G01N 33/00 (2006.01) G01N 33/533 (2006.01)
Patent
CA 2509099
Fluorogenic lysophosphatidic acid derivatives which can be used as substrates in a continuous, fluorogenic assay that can be performed in microtiter plates. The assays permit measuring LysoPLD activity levels in normal events such as pregnancy or disease states such as cancer. In addition, the present invention can be adopted to high throughout screening(HTS) for identification of potential inhibitors of lysoPLD activity.
Des dérivés d'acide lysophosphatidique fluorogènes peuvent être utilisés en tant que substrats dans un dosage fluorogène continu pouvant être effectué sur des plaques de microtitrage. Les dosages permettent de mesurer les niveaux d'activité LysoPLD dans des événements normaux tels que la grossesse ou dans des états pathologiques tels que le cancer. Cette invention peut également être utilisée pour le criblage à haute capacité permettant d'identifier des inhibiteurs potentiels de l'activité lysoPLD.
Ferguson Colin
Prestwich Glenn
Echelon Biosciences Incorporated
Smart & Biggar
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