C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/08 (2006.01) A61P 11/06 (2006.01) A61P 17/06 (2006.01) A61P 37/08 (2006.01) C07D 209/34 (2006.01) C07D 209/42 (2006.01) C07D 209/48 (2006.01) C07D 215/227 (2006.01) C07D 215/38 (2006.01) C07D 231/56 (2006.01) C07D 235/08 (2006.01) C07D 277/82 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2685215
The present invention is directed to compounds, compositions and methods useful for treating inflammatory and immune-related diseases and conditions. The compounds are modulators of prostaglandin D2 (PGD2) receptors including CRTH2 and DP receptors. The subject compounds are carboxylic acid derivatives of formulae (II) and (III): Formula (II), (III), wherein, X represents a divalent linkage selected from -O-, -S(O)k-., -CRaRb-, -C(O)-, -NR8- and -C(NR9)- Y represents a divalent linkage selected from a single bond, -S(O)kNR10-, -C(O)NR10-, (C1-C4)alkylene, hetero(C2-C4)alkyIene, -N(R11)C(O)NR10- -N(R11)S(O)kNR10-, -N(R11)CO2-, -NR11-, -O- and -S(O)k-. Z represents -CO2R12, -C(O)NR12R13 or heteroaryl. L represents a divalent linkage selected from a single bond, (C1-C6)alkylene, (C2-C6)alkenylene, (C2-C6)alkynylene and (C2-C4)heteroalkylene.
La présente invention concerne des composés, compositions et procédés qui sont utiles dans le traitement des maladies et conditions inflammatoires et des maladies liées aux troubles immunitaires. En particulier, l'invention concerne des composés qui régulent la fonction et/ou l'expression des protéines impliquées dans les maladies atopiques, les conditions inflammatoires et le cancer. Les composés de cette invention sont des dérivés d'acides carboxyliques.
Brown Matthew
Johnson Michael G.
Li An-Rong
Liu Jiwen
Lively Sarah Elizabeth
Amgen Inc.
Gowling Lafleur Henderson Llp
LandOfFree
Compounds and methods useful for treating asthma and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds and methods useful for treating asthma and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds and methods useful for treating asthma and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1792728