Compounds and peptides that bind to the erythropoietin receptor

Details Compounds and peptides that bind to the erythropoietin receptor Compounds and peptides that bind to the erythropoietin receptor

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/12 (2006.01) A61K 38/16 (2006.01) A61K 38/18 (2006.01) C07K 7/06 (2006.01) C07K 7/54 (2006.01) C07K 14/00 (2006.01) C07K 14/505 (2006.01)

Patent

CA 2223833

Peptides of 10 to 40 or more amino acid residues in length and having the sequence X3X4X5GPX6TWX7X8(SEQ ID NO:) where each amino acid is indicated by standard one letter abbreviation; X3 is C; X4 is R, H, L, or W; X5 is M, F, or I; X6 is independently selected from any one of the 20 genetically coded L-amino acids; X7 is D, E, I, L, or V; and X8 is C, which bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist, and methods for their use.

La présente invention concerne des peptides comportant dans leur longueur au moins 10 à 40 restes d'acides aminés et présentant la séquence X¿3?X¿4?X¿5?GPX¿6?TWX¿7?X¿8? (SEQ ID NO:) dans laquelle chaque acide aminé est repéré par une abréviation normalisée d'une lettre; X¿3? est C; X¿4? est R, H, L ou W; X est M, F ou I; X¿6? est choisi indépendamment parmi l'un quelconque des 20 acides aminés L génétiquement codés; X¿7? est D, E, I, L ou V; et X¿8? est C, qui se lie au récepteur de l'érythropoïétine (EPO-R) ou active ce dernier ou bien se comporte comme un agoniste de l'EPO. L'invention concerne également les procédés d'utilisation correspondants.

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