Compounds as inhibitors of cell proliferation and viral...

Details Compounds as inhibitors of cell proliferation and viral... Compounds as inhibitors of cell proliferation and viral...

C - Chemistry, Metallurgy

07

D

C07D 263/10 (2006.01) A61K 31/422 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2556616

The present invention relates to novel compounds of the general formula (I) and salts and physiologically functional derivatives thereof, formula (I) , wherein, Z is NH, or CH if Y is SO2, Y is C=O, C=S, or S02 if Z is CH; A is phenyl or indolyl, N-methyl-indolyl, R1 i s -CN, formula (II), wherein the bond between CR3 and CR7 is a single or double bond; m is 0 or 1; n is 0 or 1; p is 0 or 1; and to their use as medicaments.

La présente invention concerne de nouveaux composés de formule générale (I) et des sels et des dérivés physiologiquement fonctionnels de ceux-ci. formule (I) où Z représente NH ou CH si Y représente SO¿2?, Y représente C=O, C=S ou S0¿2? si Z représente CH; A représente phényle ou indolyle, N-méthyl-indolyle, R?1¿ représente -CN, formule (II) où la liaison entre CR?3¿ et CR?7¿ est une liaison simple ou une liaison double, m représente 0 ou 1; n représente 0 ou 1; p représente 0 ou 1. La présente invention concerne aussi l'utilisation de ces composés en tant que médicaments.

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