Compounds binding to p-selectin

Details Compounds binding to p-selectin Compounds binding to p-selectin

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/12 (2006.01) A61K 38/16 (2006.01) C07K 5/107 (2006.01) C07K 7/08 (2006.01) C07K 7/64 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2493471

The present invention relates to derivatives of compounds which bind selectively to the adhesion molecule human P-selectin, and particularly to such derivatives which comprise a peptide moiety or a functional equivalent of said peptide moiety and are represented by X(Ax)mA3A1A2A1Y. In addition, the invention relates to methods for preparing such compounds, to the use of such compounds in therapeutic or diagnostic methods and in pharmaceutical compositions, to binding molecules binding to said compounds and to a method for determining whether a compound is capable of binding to P-selectin.

La présente invention se rapporte à des dérivés de composés qui se lient sélectivement à la P-sélectine humaine qui est une molécule d'adhésion, et particulièrement aux dérivés qui comportent une fraction peptidique ou un équivalent fonctionnel de ladite fraction peptidique et sont représentés par X(A¿x?)¿m?A¿3?A¿1?A¿2?A¿1?Y. En outre, l'invention se rapporte à des procédés de préparation de ces composés, à l'utilisation de ces composés pour la mise en oeuvre de procédés thérapeutiques ou diagnostiques et dans des compositions pharmaceutiques, aux molécules de liaison se liant à ces composés et à un procédé permettant de déterminer si un composé est capable de se lier à la P-sélectine.

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