C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 38/17 (2006.01) A61P 25/00 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2457164
The present invention relates to a compound comprising the third Immunoglobulin (Ig3) module, and/or the fourth Immunoglobulin (Ig4) module, and/or the fifth Immunoglobulin (Ig5) module, and/or the first Fibronectin III (Fn3, 1) module, and/or the second Fibronectin III (Fn3, 2) module of neural cell adhesion molecule (NCAM), or a fragment, or a variant thereof, capable of interacting with a Fibroblast Growth Factor (FGF) receptor and/or Adenosine- Tri-Phosphate (ATP) and/or L1, and thereby the compounds are capable of inducing differentiation, modulating proliferation, stimulate regeneration, neuronal plasticity and/or survival of cells. Further, the present invention relates to a pharmaceutical composition comprising said compound, a process of producing a pharmaceutical composition and the use of said compound.
La présente invention concerne un composé comprenant le troisième module d'immunoglobuline (Ig3), et/ou le quatrième module d'immunoglobine (Ig4) et ou le cinquième module d'immunoglobine (Ig5), et/ou le premier module de Fibronectine III (Fn3 ,1), et/ou le deuxième module de Fibronectine III (Fn3, 2) de molécule d'adhésion cellulaire neurale (NCAM) ou un fragment ou une variante de cette dernière, pouvant agir avec le récepteur du facteur de croissance des fibroblastes (FGF) et/ou l'adénosine-triphosphate (ATP) et/ou L1. Ces composés sont ainsi capables d'induire une différentiation, de moduler la prolifération, de stimuler la regénération, la plasticité neuronale et/ou la survie des cellules. En outre, la présente invention traite d'une composition pharmaceutique comprenant ledit composé, un procédé de production d'une composition pharmaceutique et l'utilisation dudit composé.
Berezin Vladimir
Bock Elisabeth
Kiselyov Vladislav V.
Skladchikova Galina
Deeth Williams Wall Llp
Enkam Pharmaceuticals A/s
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