Compounds capable of modulating the activity and stimulating...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 9/00 (2006.01) A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01)

Patent

CA 2448174

The invention concerns novel compounds capable of modulating the activity and stimulating the production of catalytic antibodies. More particularly, the invention concerns a compound capable of increasing the activity of an antibody characterised in that it has specific affinity for the catalytic site of said antibody, and it is not immunogenic. Such compounds are useful in particular for therapeutic treatment or prevention of a pathology related to an enzymatic deficiency, to stimulate in vivo hydrolysis of xenobiotics, drugs, medicines or any other molecule potentially toxic for the organism or for preventing or inhibiting allergic reactions.

L'invention a trait à des nouveaux composés capables de moduler l'activité et de stimuler la production des anticorps catalytiques. L'invention porte en particulier sur un composé capable d'augmenter l'activité d'un anticorps catalytique caractérisé en ce qu'il a une affinité spécifique pour le site catalytique dudit anticorps, et en ce qu'il n'est pas immunogène. De tels composés sont utiles en particulier pour le traitement thérapeutique ou la prévention d'une pathologie liée à une déficience enzymatique, pour stimuler in vivo l'hydrolyse de xénobiotiques, de drogues, de médicaments ou toute autre molécule potentiellement toxique pour l'organisme ou encore pour prévenir ou empêcher des réactions allergiques.

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