C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 17/06 (2006.01) A61K 47/48 (2006.01) A61K 51/04 (2006.01) A61K 51/08 (2006.01) A61K 51/12 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) C07D 495/04 (2006.01) C07K 5/02 (2006.01) C07K 7/00 (2006.01) C07K 14/57 (2006.01) C07K 14/815 (2006.01) C07K 16/00 (2006.01) C08B 37/10 (2006.01) C12N 11/00 (2006.01)
Patent
CA 2124329
Compounds are provided having the capability of binding therapeutically active substances to lipid containing bio-compat-ible particles, such as cells or viruses. These compounds include a bio-affecting moiety, comprising a therapeutically active sub-stance, which is linked via a linking moiety to at least one hydrocarbon substituent selected so that the compounds is sufficiently non-polar to impart lipid binding capability to the compound. Thus, compounds of the invention are useful for site-selective de-livery of therapeutic agents, and retention thereof at the selected site. Methods are provided for using various compounds of the invention in treatment of diseases or other pathological conditions. For example, methods are provided for treatment of: (1) post-angioplasty restenosis; (2) rheumatoid arthritis; (3) tumor cell proliferation, particularly tumor cells associated with ovarian can-cer; and (4) psoriasis.
Baidoo Kwamena E.
Chia-En Lin
Gray Brian D.
Horan Paul K.
Jensen Bruce D.
Borden Ladner Gervais Llp
Zynaxis Technologies Incorporated
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