C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 229/64 (2006.01) A61K 31/196 (2006.01) A61K 31/606 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2405518
The present invention provides compositions and methods for prevention and prophylaxis of neurological diseases accompanied by neuronal death. The invention includes synthesis of 5-benzylamino salicylic acid (BAS) and its derivatives. BAS and its derivatives protect cortical neurons from toxic insults by N-methyl-D-aspartate, Zn2+, and reactive oxygen species. Thus, the present invention provides compositions and methods for treating stroke, traumatic brain and spinal cord injury, epilepsy, and neurodegenerative diseases that are accompanied by severe neuronal loss via excitotoxicity, Zn2+ neurotoxicity, and free radical neurotoxicity.
L'invention concerne des compositions et procédés de prévention et de prophylaxie de maladies neurologiques accompagnées par la mort des neurones. L'invention concerne la synthèse de l'acide 5-benzylaminosalicylique (BAS) et de ses dérivés. BAS et ses dérivés protègent les neurones corticaux des atteintes toxiques provoquées par le N-méthyl-D-aspartate, par Zn<2+>, et par des espèces réagissant avec l'oxygène. Ainsi, l'invention concerne des compositions et procédés de traitement des ictus, des lésions cérébrales traumatiques et de la moelle épinière, de l'épilepsie et des maladies neurodégénératives, accompagnées par une perte neuronale importante due à une excitotoxicité, à la neurotoxicité de Zn<2+> et à la neurotoxicité des radicaux libres.
Gwag Byoung Joo
Lee Young Ae
Moon Ho Sang
Ryu Bo Rum
Yoon Sung Hwa
Neurotech Co. Ltd.
Sim & Mcburney
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