C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/96 (2006.01) A61K 31/435 (2006.01) A61P 25/28 (2006.01) C07D 207/48 (2006.01) C07D 213/38 (2006.01) C07D 279/12 (2006.01) C07D 401/12 (2006.01) C07D 413/04 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2389368
The present invention relates to compounds of formula (I) wherein A, B, X, D are defined in claim 1, and pharmaceutical compositions containing them for stimulating neuroite outgrowth in nerve cells leading to nerve regeneration. These methods, compounds and compositions inhibit rotamase enzyme activity associated with binding proteins.
L'invention concerne des composés représentés par la formule (I) dans laquelle A, B, X, D sont définis dans la revendication 1, ainsi que des compositions pharmaceutiques contenant ce composés et permettant de stimuler l'élongation neuritique des cellules nerveuses donnant lieu à une régénération nerveuse. Ces méthodes, ces composés et ces compositions inhibent l'activité rotamase associée à des protéines de liaison.
Dong Liming
Guo Chuangxing
Hou Xinjun J.
Vanderpool Darin Louis
Villafranca Jesus Ernest
Agouron Pharmaceuticals Inc.
Smart & Biggar
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