Compounds, compositions and methods for the endocytic...

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/62 (2006.01) A61K 39/385 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2277582

Immunomodulating agents comprising at least one Fc receptor ligand and at least one immunosuppressive factor are provided as are methods for their manufacture and use. The immunomodulating agents may be in the form of polypeptides or chimeric antibodies and preferably incorporate an immunosuppressive factor comprising a T cell receptor antagonist. The compounds and compositions of the invention may be used to selectively suppress the immune system to treat symptoms associated with immune disorders such as allergies, transplanted tissue rejection and autoimmune disorders including lupus, rheumatoid arthritis and multiple sclerosis.

Cette invention se rapporte à des agents immunomodulateurs comportant au moins un ligand de récepteur de Fc et au moins un facteur immunosuppresseur, ainsi qu'à des procédés de fabrication et d'utilisation de tels agents. Ces immunomodulateurs peuvent se présenter sous la forme de polypeptides ou d'anticorps chimères et ils incorporent de préférence un facteur immunosuppresseur comprenant un antagoniste de récepteur des cellules thymo-dépendantes. Les composés et compositions de cette invention peuvent servir à supprimer sélectivement des réactions du système immunitaire et permettent donc de traiter des symptômes associés à des troubles du système immunitaire tels que les allergies, les rejets de tissus transplantés, et à des troubles auto-immuns tels que le lupus érythémateux, la polyarthrite rhumatoïde et la sclérose en plaques.

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