C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 49/83 (2006.01) A61K 31/05 (2006.01) A61P 25/28 (2006.01) C07C 39/15 (2006.01) C07C 39/16 (2006.01) C07C 39/17 (2006.01) C07C 43/23 (2006.01) C07C 45/62 (2006.01) C07C 45/64 (2006.01) C07C 49/835 (2006.01) C07C 69/017 (2006.01) C07C 215/50 (2006.01) C07C 235/34 (2006.01) C07C 235/38 (2006.01) C07C 235/48 (2006.01) C07C 235/54 (2006.01) C07C 235/56 (2006.01) C07C 237/22 (2006.01) C07C 275/34 (2006.01) C07D 207/16 (2006.01) C07D 213/30 (2006.01) C07D 213/66 (2006.01) C07D 213/84 (2006.01) C07D 217/26 (20
Patent
CA 2486869
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A.szlig. amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinophathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
L'invention concerne des composés bis- et tris-dihydroxyaryle et leurs analogues de méthylènedioxy et leurs esters pharmaceutiquement acceptables, leur synthèse, les compositions pharmaceutiques les contenant et leur utilisation dans le traitement de maladies amyloïdes, notamment l'amyloïdose A.beta., telle qu'elle se présente dans la maladie d' Alzheimer, l'amyloïdose IAPP, telle qu'elle se présente dans le diabète de type 2, et la synucléinophathie, telle qu'elle se présente dans la maladie de Parkinson, ainsi que la préparation de médicaments pour un tel traitement.
Castillo Gerardo M.
Coffen David L.
Lake Thomas P.
Larsen David S.
Larsen Lesley
Proteotech Inc.
Smart & Biggar
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