Compounds, compositions and methods of inhibiting...

Details Compounds, compositions and methods of inhibiting... Compounds, compositions and methods of inhibiting...

C - Chemistry, Metallurgy

07

D

C07D 221/16 (2006.01) A61K 31/381 (2006.01) A61K 31/395 (2006.01) A61K 31/4164 (2006.01) A61K 31/421 (2006.01) A61K 31/426 (2006.01) A61K 31/44 (2006.01) A61K 31/4439 (2006.01) A61K 31/473 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61K 31/53 (2006.01) A61K 31/5377 (2006.01)

Patent

CA 2580767

Compounds and compositions are provided for treatment or amelioration of one or more symptoms of .alpha.-synuclein toxicity, .alpha.-synuclein mediated diseases or diseases in which .alpha.-synuclein fibrils are a symptom or cause of the disease. In one embodiment, the compounds for use in the compositions and methods are heteroaryl acylguanidines, heteroarylhydrazones, dihydropyridones, heteroaryl and aryl styryl ketones, and heteroarylpyrazoles.

La présente invention a trait à des composés et des compositions pour le traitement ou l'amélioration d'un ou de plusieurs symptômes de la toxicité d'.alpha.-synucléine, de maladies médiées par l'.alpha.-synucléine ou de maladies dans lesquelles de fibrilles d'.alpha.-synucléine constituent un symptôme ou une cause de la maladie. Dans un mode de réalisation, les composés destinés à être utilisés dans les compositions et les procédés sont des hétéroaryle acyle guanidines, hétéroarylhydrazones, dihydropyridones, hétéroaryle et aryle styryle cétones, et hétéoarylpyrazoles.

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