C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C12N 5/12 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2753388
The present invention provides antibodies or antigen-binding fragments thereof that specifically bind the ENDO180 polypeptide and are internalized thereby, to conjugates comprising the molecules, to compositions comprising the antibodies and conjugates and to methods of using the same for delivery of therapeutic agents to cells that express the ENDO180 polypeptide on the surface of the cell for treating cell proliferative diseases or disorders and fibrosis, and for controlling (modulating) tumor progression.
L'invention concerne des anticorps ou des fragments se liant à un antigène de ceux-ci, qui se lient spécifiquement au polypeptide ENDO180 et sont internalisés par celui-ci, des conjugués comprenant ces molécules, des compositions comprenant ces anticorps et conjugués, et des méthodes d'utilisation de ceux-ci en vue de l'administration d'agents thérapeutiques à des cellules qui expriment le polypeptide ENDO180 sur la surface de la cellule, afin de traiter des maladies ou des troubles de prolifération cellulaire et la fibrose, et pour réguler (moduler) la progression tumorale.
Nelligan O'brien Payne Llp
Quark Pharmaceuticals Inc.
LandOfFree
Compounds compositions and methods of treating cancer and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds compositions and methods of treating cancer and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds compositions and methods of treating cancer and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1443407