Compounds comprising a nitric oxide moiety for inducing...

A - Human Necessities – 61 – K

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A61K 31/66 (2006.01) A61K 31/015 (2006.01) A61K 31/04 (2006.01) A61K 31/05 (2006.01) A61K 31/122 (2006.01) A61K 31/352 (2006.01) A61K 31/353 (2006.01) A61K 31/397 (2006.01) A61K 31/40 (2006.01) A61K 31/404 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) A61P 3/06 (2006.01) A61P 9/00 (2006.01) C07C 15/18 (2006.01) C07D 215/04 (2006.01) C07D 215/233 (2006.01) C07D 311/36 (2006.01) C07D 311/38 (2006.01)

Patent

CA 2545479

Compounds for inducing the expression of ApoA1, comprising a donatable nitric oxide moiety and a free-radical scavenging moiety. Preferably, nitric oxide derivatives of stilbenes, polyphenols, flavonoids and isoflavonoids and methods of their use are provided for treating patients suffering from diseases including hypercholesterolemia, vascular oxidative stress and endothelial dysfunction.

L'invention concerne des composés permettant d'induire l'expression de ApoA1 ce qui favoriser l'augmentation des niveaux sanguins de HDL et la réduction des niveaux sanguins de cholestérol, et comprenant une fraction d'acide nitrique apte à être donnée et une fraction de piégeage à radical libre. Les dérivés d'acide nitrique de stilbènes, les polyphénols, les flavonoïdes et les inflavonoïdes et leurs procédés sont, de préférence, utilisés pour traiter des patients souffrant d'hypercholestérolémie, de stress oxidatif vasculaire et de dysfonction endothéliale.

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