C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 263/14 (2006.01) C07D 207/06 (2006.01) C07D 263/16 (2006.01) C07D 263/32 (2006.01) C07D 263/36 (2006.01) C07D 263/52 (2006.01) C07D 277/10 (2006.01) C07D 277/24 (2006.01) C07D 277/28 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2602336
The present invention relates to compounds comprising an oxazole or thiazole moiety of formula (I), processes for preparing them, pharmaceutical compositions comprising said compounds and their uses as H3 -receptor ligands, Formula (I), wherein , A1 is CH, C(alkyl), C-halogen or N; Rl is hydrogen, halogen, C1-6 alkyl or alkoxy; R2 is, Formula (II~), A3 is O or S; R3 is hydrogen, halogen, C1-6 alkyl or alkoxy; R4 is hydrogen, halogen, C1-6 alkyl, alkoxy or -O-L; R5 is hydrogen or -O-L, wherein L is an aminoalkyl group and at least one of R4 and R5 should be -O-L.
La présente invention concerne des composés comprenant un groupe fonctionnel à base d'oxazole ou de thiazole ayant la formule (I), des processus de préparation, des compositions pharmaceutiques comprenant ces composés et leur utilisation en tant que ligands de récepteurs H3, formule (I), dans laquelle A1 et CH, C(alkyle), C-halogène ou N; R1 est hydrogène, halogène, alkyle ou alcoxy C1-6; R2 est, formule (II'), A3 est O ou S; R3 est hydrogène, halogène, alkyle ou alcoxy C1-6; R4 est hydrogène, halogène, alkyle ou alcoxy C1-6 ou -O-L; R5 est hydrogène ou -O-L, dans laquelle L est un groupe aminoalkyle, au moins des R4 et R5 devant être -O-L.
Celanire Sylvain
Denonne Frederic
Robic
Ucb Pharma S.a.
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