C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 263/14 (2006.01) C07D 207/06 (2006.01) C07D 263/16 (2006.01) C07D 263/32 (2006.01) C07D 263/36 (2006.01) C07D 263/52 (2006.01) C07D 277/10 (2006.01) C07D 277/24 (2006.01) C07D 277/28 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2602339
The present invention relates to compounds comprising an oxazoline or thiazoline moiety, processes for preparing them, pharmaceutical compositions comprising said compounds and their uses as H3-receptor ligands, (I), wherein A1 is CH C(CH3) or N; R1 is hydrogen or halogen; R2 is (II); A2 is O or S; R3 is hydrogen, halogen, C1 - 4 alkyl or C1-4 alkoxy; R4 is hydrogen, halogen, C1- 4 alkyl, C1-4 alkoxy, trifluoromethyl or -O-(CH2)n- NR12a R each CH2 in -O- (CH2)n-NR12a R12b being optionally substituted by one or two C1-4 alkyl; R5 is hydrogen or -O-(CH2)m-NR13a R 13b, each CH2 in-O-(CH2)m-NR13aR13 b being optionally substituted by one or two C1-4 alkyl, and at least one of R4 and R5 should be a -O-(CH2)n-NR12/13a R12/13b group.
The present invention relates to compounds comprising an oxazoline or thiazoline mmoiety, processes for preparing them, pharmaceutical compositions comprising said compounds and their uses as H3-receptor ligands, Formula (I), wherein A1 is CH C(CH3) or N; R1 is hydrogen or halogen; R2 is Formula (II); A2 is O or S; R3 is hydrogen, halogen, C1-4 alkyl or C1-4 alkoxy; R4 is hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, trifluoromethyl or -O-(CH2)n- NR12a R each CH2 in -O-(CH2)n-NR12a R12b being optionally substituted by one or two C1-4 alkyl; R5 is hydrogen or -O-(CH2)m-NR13 aR 13b, each CH2 in-O-(CH2)m-NR13aR 13 b being optionally substituted by one or two C1-4 alkyl.
Celanire Sylvain
Denonne Frederic
Lebon Florence
Leurs Regorius
Talaga Patrice
Robic
Ucb Pharma S.a.
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