Compounds containing a bicyclic ring system useful as alpha...

Details Compounds containing a bicyclic ring system useful as alpha... Compounds containing a bicyclic ring system useful as alpha...

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/4427 (2006.01) A61K 31/553 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07D 213/73 (2006.01) C07D 213/74 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2419255

The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha.v.beta.3 and/or .alpha.v.beta.5 integrin. The ring A-B, is selected from the group consisting of the formula II all optionally substituted and bonded to X and Z1 at any position.

La présente invention se rapporte à une classe de composés représentés par la formule (I) ou à un sel pharmaceutiquement acceptable de tels composés, à des compositions pharmaceutiques contenant des composés de formule (I) et à des méthodes permettant d'inhiber ou d'antagoniser sélectivement l'intégrine .alpha.v.beta.¿3? et/ou .alpha.v.beta.¿5?. Le noyau A-B est sélectionné dans le groupe constitué par les noyaux de la figure (II), tous éventuellement substitués et liés à X et à Z¿1? en une position quelconque.

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