Compounds containing a michael-acceptor, especially...

C - Chemistry – Metallurgy – 07 – C

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C07C 235/76 (2006.01) A61Q 17/04 (2006.01) C07C 69/60 (2006.01) C07C 233/20 (2006.01) C07C 233/33 (2006.01) C07C 233/55 (2006.01) C07D 207/452 (2006.01)

Patent

CA 2189337

The present invention relates to compounds which are useful as sunscreens. The compounds persists on the skin for much longer than conventional sunscreens because they comprise a Michael acceptor linked directly or indirectly to a chromophore. The Michael acceptor is capable of undergoing a conjugate addition reaction with thiol groups present in cysteine residues of keratin and thus the compound is chemically bound to the skin and will not be removed by immersion in water.

L'invention concerne des composés efficaces en tant qu'écran total. Ces composés restent sur la peau beaucoup plus longtemps que les produits classiques d'écran total, étant donné qu'ils comprennent un accepteur de Michael lié directement ou indirectement à un chromophore. L'accepteur de Michael est capable de subir une réaction d'addition conjugée avec des groupes thiol présents dans des résidus de cystéine de kératine et, de ce fait, le composé se fixe chimiquement à la peau et restera insensible à l'immersion dans l'eau.

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