Compounds containing six-membered rings, processes for their...

Details Compounds containing six-membered rings, processes for their... Compounds containing six-membered rings, processes for their...

A - Human Necessities

61

K

A61K 31/215 (2006.01) A61K 31/196 (2006.01) A61P 31/16 (2006.01) C07C 233/52 (2006.01)

Patent

CA 2303323

Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

L'invention concerne de nouveaux composés qui, en général, comprennent un groupe acide, un groupe basique, un amino ou N-acyl à substitution et un groupe comportant une fraction alcane facultativement hydroxylée. L'invention concerne également des compositions pharmaceutiques renfermant les inhibiteurs décrits. L'invention concerne en outre des procédés qui permettent d'inhiber la neuraminidase dans des échantillons dont on suspecte qu'ils contiennent ladite neuraminidase. L'invention concerne enfin des matériaux antigéniques, des polymères, des anticorps, des conjugués des composés considérés munis de marqueurs, et des procédés de dosage qui permettent de déceler l'activité de la neuraminidase.

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