A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/422 (2006.01) C07D 263/32 (2006.01) C07D 263/48 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2348234
The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5'-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH mediated diseases, such as transplant rejection and autoimmune diseases.
La présente invention concerne l'identification des nouveaux inhibiteurs de l'IMPDH (inosine-5'-monophosphate déshydrogénase). Les composés et les compositions pharmaceutiques décrits dans l'invention sont utiles dans le traitement ou dans la prévention de maladies induites par IMPDH, telles que le rejet de greffes et les maladies auto-immunes.
Dhar T. G. Murali
Gu Henry H.
Iwanowicz Edwin J.
Leftheris Katerina
Liu Chunjian
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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