Compounds derived from thophene and benzothiophene, and...

C - Chemistry – Metallurgy – 07 – D

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C07D 333/22 (2006.01) A61K 31/495 (2006.01) C07D 333/20 (2006.01) C07D 333/28 (2006.01) C07D 333/32 (2006.01) C07D 333/42 (2006.01) C07D 333/44 (2006.01) C07D 333/56 (2006.01) C07D 333/58 (2006.01) C07D 333/64 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2295715

Compounds derived from thiophene and benzothiophene and related utilisation and composition; the compounds have the formula (I) where Z is -CO-, -CH(OR6), -C(NOR7)-; R1 is H, alkyle C1-C6, halogen, or -O-R12; R2 and R3 are H, alkyle, halogen, nitro or -O-R12 or R2 and R3 are together -CR8=CR9-CR10=CR11; R4 and R5 are H, alkyle, halogen, haloalkyle, OR12, nitro, -NR13R14; -CO2R12; - SO2NR13R14; -SO2R12; -SR12, cyano; -CONR13R14 or R4 and R5 form together a benzin ring; R6 is H, alkyle, -CO2R12, -C(O)NR13R14 napthyle ou phenyle; R7 is H or alkyle; R8, R9, R10 and R11 are H, alkyle, halogen, -OR12, nitro, cyano, - NR13R14, -COR12, -CO2R12, SO2NR13R14, -SO2R12, -SR12, -CONR13R14; R12 is H, alkyle C1-C6, or phenyle; and R13 and R14 are H, alkyle or phenyle or R13 and R14 form a ring of 5 or 6 members. These compounds are efficient for the treatment of anxiety or depression.

L'invention concerne des composés dérivés de thiophène et benzothiophène, leur utilisation et leur composition. Les composés sont de formule (I) dans laquelle Z désigne -CO-, -CH(OR¿6?)-, -C(NOR¿7?)-; R¿1? désigne H, alkyle en C¿1?-C¿6?, halogène ou -O-R¿12?; R¿2? et R¿3? désignent H, alkyle, halogène, nitro ou -O-R¿12? ou R¿2? et R¿3? désignent pris ensemble -CR¿8?=CR¿9?-CR¿10?=CR¿11?; R¿4? et R¿5? désignent H, alkyle, halogène, haloalkyle, OR¿12?, nitro, -NR¿13?R¿14?; -COR¿12?; -CO¿2?R¿12?; -SO¿2?NR¿13?R¿14?; -SO¿2?R¿12?; -SR¿12?, cyano; -CONR¿13?R¿14? ou R¿4? et R¿5? forment un noyau benzénique, R¿6? désigne H, alkyle, -CO¿2?R¿12?, -C(O)NR¿13?R¿14? napthyle ou phényle; R¿7? désigne H ou alkyle; R¿8?, R¿9?, R¿10? et R¿11? désignent H, alkyle halogène, -OR¿12?, nitro, cyano, -NR¿13?R¿14?, -COR¿12?, -CO¿2?R¿12?, -SO¿2?NR¿13?R¿14?, -SO¿2?R¿12?, -SR¿12?, -CONR¿13?R¿14?; R¿12? désigne H, alkyle en C¿1?-C¿6?, ou phényle; et R¿13? et R¿14? désignent H, alkyle ou phényle ou R¿13? et R¿14? désignent un noyau à 5 ou 6 chaînons. Ces composés sont efficaces pour le traitement de l'anxiété ou de la dépression.

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