C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 243/10 (2006.01) A61K 31/55 (2006.01) C07D 223/14 (2006.01) C07D 243/24 (2006.01) C07D 243/38 (2006.01) C07D 267/12 (2006.01) C07D 267/14 (2006.01) C07D 267/20 (2006.01) C07D 281/08 (2006.01) C07D 281/10 (2006.01) C07D 281/16 (2006.01) C07D 403/04 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)
Patent
CA 2233012
Compounds represented by general formula (I) or (II) or salts thereof which are useful as a retinoid potentiator, wherein R1 represents hydrogen or C1-6 alkyl; R2 and R3 represent each hydrogen or C1-6 alkyl, or R2 and R3 together form 5- or 6-membered cycloalkyl; R4 represents hydrogen, C1-6 alkyl, etc.; R5 represents hydrogen, C1-6 alkyl, etc.; R6 represents hydrogen or C1-6 alkyl; X represents -NR7-, -O-, -CHR7- or -S-, wherein R7 represents hydrogen, C1-6 alkyl, etc.; and Y represents phenylene or pyridinediyl.
L'invention concerne des composés représentés par les formules générales (I) ou (II) ou de celles de ces composés qui tiennent lieu de potentialisateurs de rétinoïde. Dans lesdites formules, R?1¿ est hydrogène ou alkyle C¿1-6?, ou R?2¿ and R?3¿ donnent ensemble cycloalkyle à 5- ou 6-chaînons; R?4¿ est hydrogène, alkyle C¿1-6?, etc.; R?5¿ est hydrogène, alkyle C¿1-6?, etc.; R?6¿ est hydrogène ou alkyle C¿1-6?; X est -NR?7¿-, -O-, -CHR?7¿- ou -S-, et R?7¿ représente en l'occurrence hydrogène, alkyle C¿1-6?, etc.; et Y est phénylène ou pyridinediyle.
Dennison Associates
Institute Of Medicinal Molecular Design. Inc.
Nikken Chemicals Co. Ltd.
Shudo Koichi
LandOfFree
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