C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/605 (2006.01) A61K 38/26 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2702289
Glucagon analogs are disclosed that exhibit both glucagon antagonist and GLP-1 agonist activity. In one embodiment, the glucagon antagonist/GLP-1 agonist comprises a modified amino acid sequence of native glucagon, in which the first one to five N-terminal amino acids of native glucagon is deleted and in which the alpha helix is stabilized.
L'invention concerne des analogues du glucagon présentant une activité d'antagonistes du glucagon et d'agonistes du GLP-1. Dans un mode de réalisation, l'antagoniste du glucagon/agoniste du GLP-1 comprend une séquence d'acides aminés modifiée de glucagon natif, dans laquelle le premier des cinq acides aminés à terminaison N de glucagon natif est supprimé et l'hélice alpha est stabilisée.
Dimarchi Richard D.
Ouyang Chenguang
Yang Bin
Indiana University Research And Technology Corporation
Smart & Biggar
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