Compounds for alzheimer's disease

Details Compounds for alzheimer's disease Compounds for alzheimer's disease

C - Chemistry, Metallurgy

07

D

C07D 209/04 (2006.01) A61K 31/404 (2006.01)

Patent

CA 2582674

The invention provides novel compounds useful for the treatment of neurodegenerative disorders including Alzheimer's disease and dementia. The compounds have a substituents chosen from -L-C(=O)OH, -L-CH=CHC(=O)OH, -L- C(=O)NH2, -L-C(=O)NH(C1-3 alkyl), -L-C(=O)N(C1-3 alkyl)2, -L-S(=O)2(C1- 3alkyl), -L-S(=O)2NH2, -L-S(=O)2N(C1-3 alkyl)2, -L-S(=O)2NH(C1-3 alkyl), -L- C(=O)NHOH, -L-C(=O)CH2NH2, -L-C(=O)CH2OH, -L-C(=O)CH2SH, -L-C(=O)NHCN, -L- NHC(=O)ORo, -L-C(=O)NHRo, -L-NH(C=O)NHRo, -L-C(=O)N(Ro)2, -L-NH(C=O)N(Ro)2, -L- sulfo, -L-(2,6 difluorophenol), -L-phosphono, and -L-tetrazolyl, where L is a linker.

L'invention concerne de nouveaux composés utilisés dans le traitement de troubles neurodégénératifs, y compris, la maladie d'Alzheimer et la démence. Ces composés présentent un substituant choisi parmi -L-C(=O)OH, -L-CH=CHC(=O)OH, -L-C(=O)NH2, -L-C(=O)NH(C1-3 alkyle), -L-C(=O)N(C1-3 alkyle)2, -L-S(=O)2(C1-3 alkyle), -L-S(=O)2NH2, -L-S(=O)2N(C1-3 alkyle)2, -L-S(=O)2NH(C1-3 alkyle), -L-C(=O)NHOH, -L-C(=O)CH2NH2, -L-C(=O)CH2OH, -L-C(=O)CH2SH, -L-C(=O)NHCN, -L-NHC(=O)OR<SB>O</SB>, -L-C(=O)NHR<SB>O</SB>, -L-NH(C=O)NHR<SB>O</SB>, -L-C(=O)N(R<SB>O</SB>)2, -L-NH(C=O)N(R<SB>O</SB>)2, -L-sulfo, -L-(2,6 difluorophénol), -L-phosphono, et -L-tétrazolyle, où L représente un lieur.

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