C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/75 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/27 (2006.01) A61K 31/275 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) C07C 45/30 (2006.01) C07C 235/38 (2006.01) C07C 271/00 (2006.01) C07C 271/60 (2006.01) C07D 213/73 (2006.01) C07D 213/74 (2006.01) C07D 213/76 (2006.01) C07D 239/52 (2006.01) C07D 239/54 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2209125
Novel compounds which are effective PDE IV inhibitors are disclosed. The compounds possess improved PDE IV inhibition as compared to theophylline or rolipram as well as with improved selectivity with regard to PDE III inhibition. In certain aspects of the invention, the compounds also demonstrate PDE V inhibition. Pharmaceutical compositions containing the same and methods of treatment are also disclosed.
Cette invention se rapporte à de nouveaux composés qui sont efficaces comme inhibiteurs de la PDE IV. Ces composés possèdent un pouvoir d'inhibition de la PDE IV accrû par rapport à la théophylline ou au rolipram, ainsi qu'une sélectivité accrue par rapport à l'inhibition de la PDE III. Dans certains aspects de cette invention, ces composés présentent également un pouvoir d'inhibition de la PDE V. Des compositions pharmaceutiques contenant ces composés et des procédés thérapeutiques sont également décrits.
Cavalla David J.
Chasin Mark
Dolby Lloyd
Borden Ladner Gervais Llp
Euro-Celtique S.a.
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