Compounds for cancer imaging and therapy

Details Compounds for cancer imaging and therapy Compounds for cancer imaging and therapy

A - Human Necessities

61

K

A61K 51/04 (2006.01) C07B 59/00 (2006.01) C07D 295/13 (2006.01) C07D 307/79 (2006.01) C07C 5/00 (2006.01)

Patent

CA 2215839

The present invention relates to a class of compounds having affinity for certain cancer cells, e.g. lung carcinomas, colon carcinomas, renal carcinomas, prostate carcinomas, breast carcinomas, malignant melanomas, gliomas, neuroblastomas and pheochromocytomas. The compounds of the present invention can also bind with high specificity to cell surface sigma receptors and can therefore be used for diagnostic imaging of any tissue having an abundance of cells with sigma receptors. The present invention provides such compounds as agents for diagnostic imaging and for detecting and treating tumors containing the cancer cells described above.

La présente invention se rapporte à une catégorie de composés ayant une affinité pour certaines cellules cancéreuses, par exemple pour les cancers du poumon, du colon, les cancers rénaux, de la prostate, du sein, les mélanomes malins, les gliomes, les neuroblastomes et les phéochromocytomes. Les composés décrits peuvent aussi se fixer à un degré de spécificité élevé aux récepteurs sigma de surfaces cellulaires, ce qui permet de les utiliser pour l'imagerie diagnostique relative à tout tissu possédant une multitude de cellules à récepteurs sigma. La présente invention concerne des composés tels que des agents permettant l'imagerie diagnostique relative aux tumeurs contenant les cellules cancéreuses décrites ci-dessus, ainsi que leur détection et leur traitement.

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