C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/15 (2006.01) A61K 51/00 (2006.01) A61K 51/04 (2006.01) C07B 59/00 (2006.01) C07C 233/78 (2006.01) C07C 235/60 (2006.01) C07D 207/09 (2006.01) C07D 209/08 (2006.01) C07D 211/26 (2006.01) C07D 295/13 (2006.01) C07D 307/79 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2139503
2139503 9426314 PCTABScor01 The present invention relates to compounds having affinity for certain cancer cells, e.g. lung carcinomas, colon carcinomas, renal carcinomas, malignant melanomas, gliomas, neuroblastomas and pheochromocytomas. The compounds also bind with high specificity to cell surface sigma receptors and can therefore be used for diagnostic imaging of any tissue having an abundance of cells with sigma receptors. The compounds are of general formula (I) wherein X is a radionuclide; R2 is -N(R3)2 or a 5 to 6 member nitrogen containing heterocyclic ring, optionally substituted with at least one alkyl group; the remaining variables are defined on page 5 of the disclosure. Methods are provided for diagnostic imaging and for the detection and treatment of tumors containing the cancer cells described above.
Baumgold Jesse
John Christy S.
Mcafee John G.
Moody Terry W.
Baumgold Jesse
John Christy S.
Mcafee John G.
Mcfadden Fincham
Moody Terry W.
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