A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/00 (2006.01) A61K 39/00 (2006.01) A61M 36/14 (2006.01)
Patent
CA 2634217
Disclosed are compounds containing single amino acids, peptides, or derivatives thereof which are selectively delivered to the mitochondria of a cell . Compounds of the invention exhibit antioxidant activity thereby reducing reactive oxygen species in cells. These compounds are useful for inhibiting oxidative stress- induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.
L'invention concerne des composés contenant des acides aminés simples, des peptides ou des dérivés de ceux-ci, distribués de manière sélective aux mitochondries d'une cellule. Les composés de l'invention présentent une activité antioxydante, réduisant ainsi les espèces d'oxygène réactives dans les cellules. Ces composés sont utilisés pour inhiber une lésion ou une mort cellulaire induite par le stress oxydatif à la fois in vivo et ex vivo. L'invention concerne, de plus, des procédés de synthèse desdits composés.
Anders Marion W.
Nauduri Dhananjaya
Sharma Virendra K.
Sheu Shey-Shing
Xu Lin
Borden Ladner Gervais Llp
University Of Rochester
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