C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) C07K 14/35 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2290754
Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
L'invention concerne des composés et des procédés permettant de diagnostiquer la tuberculose. Lesdits composés sont notamment des polypeptides renfermant au moins une partie antigénique d'une ou de plusieurs protéines de M. tuberculosis, et les séquences d'ADN codant de ces polypeptides. On peut utiliser des kits de diagnostic contenant ces polypeptides ou ces séquences d'ADN et un réactif de détection approprié pour détecter une infection par M. tuberculosis chez des patients et dans des échantillons biologiques. L'invention concerne également des anticorps dirigés contre ces polypeptides.
Alderson Mark R.
Campos-Neto Antonio
Dillon Davin C.
Skeiky Yasir A. W.
Alderson Mark R.
Campos-Neto Antonio
Corixa Corporation
Dillon Davin C.
Fetherstonhaugh & Co.
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