Compounds for diseases and disorders

Details Compounds for diseases and disorders Compounds for diseases and disorders

A - Human Necessities

61

K

A61K 31/404 (2006.01) A61K 31/435 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2648652

The invention provides novel compounds useful for the treatment of disorders associated with a defect in vesicular transport (e.g., axonal transport). The compounds have a substituents chosen from -L-C(=O)OH, -L-CH=CHC(=O)OH, -L-C(=O)NH2, -L-C(=O)NH(C1-3 alkyl), -L-C(=O)N(C1-3 alkyl)2, -L-S(=O)2(C1-3alkyl), -L-S(=O)2NH2, -L-S(=O)2N(C1-3 alkyl)2, -L-S(=O)2NH(C1-3 alkyl), -L-C(=O)NHOH, -L-C(=O)CH2NH2, -L-C(=O)CH2OH, -L-C(=O)CH2SH, -L-C(=O)NHCN, -L-NHC(=O)ORo, -L-C(=O)NHRo, -L-NH(C=O)NHRo, -L-C(=O)N(Ro)2, -L-NH(C=O)N(Ro)2, -L-sulfo, -L-(2,6 difluorophenol), -L-phosphono, and -L-tetrazolyl, where L is a linker.

L'invention concerne de nouveaux composés utiles pour le traitement de troubles associés à un défaut dans le transport vésiculaire (par exemple le transport axonal). Les composés ont des substituants choisis parmi -L-C(=O)OH, -L-CH=CHC(=O)OH, -L-C(=O)NH2, -L-C(=O)NH(alkyle en C1-3), -L-C(=O)N(alkyle en C1-3)2, -L-S(=O)2(alkyle en C1-3), -L-S(=O)2NH2, -L-S(=O)2N(alkyle en C1-3)2, -L-S(=O)2NH(alkyle en C1-3), -L-C(=O)NHOH, -L-C(=O)CH2NH2, -L-C(=O)CH2OH, -L-C(=O)CH2SH, -L-C(=O)NHCN, -L-NHC(=O)OR0, -L-C(=O)NHR0, -L-NH(C=O)NHR0, -L-C(=O)N(R0)2, -L-NH(C=O)N(R0)2, -L-sulfo, -L-(2,6-difluorophénol), -L-phosphono et -L-tétrazolyle, où L est un groupe de liaison.

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