Compounds for dual photodiagnosis and therapy

Details Compounds for dual photodiagnosis and therapy Compounds for dual photodiagnosis and therapy

C - Chemistry, Metallurgy

09

B

C09B 47/00 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2542694

The invention discloses compounds and compositions for dual phototherapy and combined therapy and diagnosis of tumors and other lesions. The compounds have a Dye that, when photoactivated, operates via Type I and/or Type II mechanisms. Other Dye or azide components may operate by the same or different mechanisms. Selection of particular components in a compound, and formulation of the compound(s) in a composition permit different activation wavelengths to be used for different therapies. A targeting moiety may be added to the compound or composition so that the Dye locates at a particular site, such as a hormone-sensitive tumor, for diagnosis and/or treatment. The compounds and compositions may be incorporated within liposomes.

L'invention concerne des composés et des compositions de double photothérapie et thérapie et diagnostic combinés de tumeurs et d'autres lésions. Les composés comprennent un colorant qui, lorsqu'il est photoactivé, fonctionne par des mécanismes de type I et/ou de type II. Un autre colorant ou des constituants azide peuvent fonctionner selon des mécanismes identiques ou différents. La sélection de constituants particuliers dans un composé et la formulation du composé ou des composés dans une composition permet d'utiliser différentes longueurs d'ondes d'activation pour des thérapies différentes. Une fraction de ciblage peut être ajoutée au composé ou à la composition de manière que le colorant se localise sur un site particulier tel qu'une tumeur hormono-sensible pour un diagnostic et/ou un traitement. Les composés et les compositions peuvent être contenus à l'intérieur de liposomes.

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