Compounds for immunotherapy and diagnosis of colon cancer...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/14 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2396036

Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.

L'invention concerne des compositions et des procédés pour la thérapie et le diagnostic du cancer, tel que le cancer du côlon. Ces compositions peuvent comprendre une ou plusieurs protéines tumorales du côlon, des parties immunogènes de ces dernières ou des polynucléotides qui codent ces protéines. Par ailleurs, une composition thérapeutique peut comprendre une cellule de présentation d'un antigène qui exprime une protéine tumorale du côlon, ou un lymphocyte T qui est spécifique pour les cellules exprimant cette protéine. Ces compositions peuvent être utilisées, par exemple, pour la prévention et le traitement de maladies comme le cancer du côlon. L'invention traite de procédés de diagnostique mettant en oeuvre la détection d'une protéine tumorale du côlon, ou un ARNm codant pour cette protéine, dans un échantillon.

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