Compounds for inhibiting beta-amyloid production

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/472 (2006.01) A61P 25/28 (2006.01) C07D 217/22 (2006.01)

Patent

CA 2644240

Provided are compounds useful for treating diseases associated with a cerebral accumulation of Alzheimer's amyloid, such as Alzheimer's disease. Also provided are methods of treating or reducing the risk of developing .beta.-amyloid production, .beta.-amyloid deposition, .beta.-amyloid neurotoxicity (including abnormal hyperphosphorylation of tau) and microgliosis associated with cerebral accumulation of Alzheimer's amyloid by administering therapeutically effective amounts of the compounds. Further provided are methods for diagnosing diseases associated with cerebral accumulation of Alzheimer's amyloid in animals or humans by administering diagnostically effective amounts of the compounds.

La présente invention concerne des composés utiles pour le traitement de maladies associées à une accumulation cérébrale de l'amyloïde d'Alzheimer telles que la maladie d'Alzheimer. La présente invention concerne également des procédés de traitement ou de réduction du risque de développement de la production de .beta.-amyloïde, du dépôt de .beta.-amyloïde, de la neurotoxicité de la .beta.-amyloïde (dont l'hyperphosphorylation de tau) et de la microgliose associés à l'accumulation de l'amyloïde d'Alzheimer en administrant des quantités thérapeutiquement efficaces de composés. L'invention concerne en outre des procédés destinés à diagnostiquer des maladies associées à l'accumulation cérébrale de l'amyloïde d'Alzheimer chez des animaux ou des humains en administrant des quantités diagnostiquement efficaces des composés.

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