Compounds for inhibiting diseases and preparing cells for...

Details Compounds for inhibiting diseases and preparing cells for... Compounds for inhibiting diseases and preparing cells for...

A - Human Necessities

61

K

A61K 35/12 (2006.01) A61K 31/00 (2006.01) A61K 31/185 (2006.01) A61K 31/194 (2006.01) A61K 31/44 (2006.01) A61K 31/4418 (2006.01) A61K 31/47 (2006.01) A61K 31/472 (2006.01) A61K 31/66 (2006.01) A61P 25/28 (2006.01) C07K 14/47 (2006.01) C12N 5/02 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2375628

Methods and compositions which are useful in the treatment of amyloidosis. In particular, methods and compositions are provided for inhibiting, preventing and treating amyloid depositions, e.g. in pancreatic islets, wherein the amyloidotic deposits are islet amyloid polypeptide (IAPP)-associated amyloid deposition or deposits. The methods of the invention involved administering to a subject a therapeutic compound which inhibits IAPP-associated amyloid deposits. Accordingly, the compositions and method of the invention are useful for inhibiting IAPP-associated amyloidosis in disorders in which such amyloid deposition occurs, such an diabetes. The invention also provides a process for the preparation of cells suitable for transplantation into a mammal, which cells are capable of forming fibrils, said process comprising contacting the cells with an inhibitor of fibril formation. In particular the process prepares cells for use in a method of treating diabetes. Also provided are a culture medium comprising the inhibitor and cells for transplantation.

L'invention concerne des procédés et des compositions utiles dans le traitement de l'amylose. L'invention concerne en particulier des procédés et des compositions utiles pour l'inhibition, la prévention et le traitement des dépôts amyloïdes, par exemple dans les îlots pancréatiques, lesdits dépôts étant alors des dépôts amyloïdes associés aux polypeptides amyloïdes des îlots. Les procédés décrits consistent à administrer au sujet un composé thérapeutique inhibant les dépôts amyloïdes associés aux polypeptides amyloïdes des îlots. Les compositions et les procédés considérés sont donc utiles pour inhiber les dépôts amyloïdes associés aux polypeptides amyloïdes des îlots dans les troubles caractérisés par ce type d'amylose, comme le diabète. L'invention concerne également un processus de préparation de cellules convenant pour une transplantation chez un mammifère, ces cellules pouvant former des fibrilles. Ce processus consiste à mettre les cellules en contact avec un inhibiteur de la formation de fibrilles et prépare notamment les cellules destinées à être utilisées dans un traitement du diabète. L'invention concerne en outre un milieu de culture contenant ledit inhibiteur et les cellules à transplanter.

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