C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/4743 (2006.01) A61K 31/496 (2006.01) A61K 31/695 (2006.01) A61P 35/00 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2599901
The present invention provides compounds of Formula I (wherein R1, R3, X, W, Z and ring Y are as defined herein). The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases or disorders associated with KSP kinesin activity and for inhibiting KSP kinesin activity.
La présente invention concerne des composés représentés par la formule (I) (dans laquelle R1, R3, X, W, Z et le noyau Y sont comme définis dans le descriptif). L'invention concerne également des compositions, renfermant ces composés, qui conviennent pour le traitement de maladies à prolifération cellulaire ou de troubles associés à l'activité de la kinésine KSP, activité qu'elles permettent d'inhiber.
Guzi Timothy J.
Kerekes Angela D.
Labroli Marc
Paliwal Sunil
Poker Cory
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Schering Corporation
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