C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/54 (2006.01) A61K 31/415 (2006.01) A61P 35/00 (2006.01) C07D 471/00 (2006.01) C07D 493/00 (2006.01)
Patent
CA 2702990
The present invention relates to compounds of Formula (I), below, (wherein X, R1, R2, R3, R27, R28, p, E, ring A, and ring B are as defined herein). The present invention also relates to compositions (including pharmaceutically acceptable compositions) comprising these compounds, alone and in combination with one or more additional therapeutic agents, and to methods for their use in inhibiting KSP kinesin activity, and for treating cellular proliferative diseases or disorders associated with KSP kinesin activity.
La présente invention porte sur des composés représentés par la Formule (I), ci-après, (dans laquelle X, R1, R2, R3, R27, R28, p, E, le cycle A et le cycle B sont tels que définis présentement). La présente invention porte également sur des compositions (comprenant des compositions pharmaceutiquement acceptables) comprenant ces composés, individuellement ou en association avec un ou plusieurs agents thérapeutiques supplémentaires, et sur des procédés permettant de les utiliser dans l'inhibition de l'activité de la kinésine de KSP et pour traiter des maladies ou troubles de la prolifération cellulaire associés avec une activité de la kinésine KSP.
Angeles Angie R.
Cheng Cliff C.
Dai Chaoyang
Huang Xiaohua
Mansoor Umar Faruk
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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