Compounds for intracellular delivery of therapeutic moieties...

Details Compounds for intracellular delivery of therapeutic moieties... Compounds for intracellular delivery of therapeutic moieties...

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2356454

A compound for delivering a non-cytotoxic therapeutic moiety into nerve cells, the compound having the general formula : B-L-TM where: B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; TM is a therapeutic moiety which has a non-cytotoxic therapeutic effect when absorbed by a nerve cell; and L is a linker coupling B to TM.

L'invention concerne un composé permettant d'administrer un groupe caractéristique thérapeutique non cytotoxique dans les cellules nerveuses. Ce composé est de formule: B-L-TM dans laquelle B désigne un agent de liaison capable de se lier de manière sélective à un récepteur de surface cellulaire nerveuse et d'absorber le composé par le biais de la cellule nerveuse ; TM désigne un groupe caractéristique thérapeutique ayant un effet thérapeutique non cytotoxique lorsqu'il est absorbé par une cellule nerveuse et L désigne une séquence de liaison associant B à TM.

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