C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 255/41 (2006.01) A61K 31/4402 (2006.01) A61P 35/00 (2006.01) C07C 255/32 (2006.01) C07C 255/38 (2006.01) C07D 213/71 (2006.01)
Patent
CA 2533287
Compounds having the Formula (I) or (III) wherein R1, R2 and R3 are each independently selected from H, OH, C1-6alkyl, C1-6alkoxy, NH2, NH-(Cl-6a1kyl), N(C1-6a1kyl)(C1-6alkyl), SH, S-C1-6alkyl, NO2, CF3, OCF3, and halo; R4 is unsubstituted Ar or Ar substituted with 1-4 substituents independently selected from C1-6alkyl, C1-6alkoxy and halo; X is selected from (CH2CH2O)n and (CH)n, and n = 1-4, salts, solvates and hydrates thereof, useful for modulating or inhibiting cell proliferation, are described.
L'invention concerne des composés représentés par la formule (I) ou (III), dans laquelle R?1¿, R?2¿ et R?3¿ sont chacun indépendamment choisis parmi H, OH, C¿1-6?alkyle, C¿1-6?alcoxy, NH¿2?, NH-(C¿1-6?alkyle), N(C¿1-6?alkyle)(C¿1-6?alkyle), SH, S-C¿1-6?alkyle, NO¿2?, CF¿3?, OCF¿3? et halo, R?4¿ est Ar non substitué ou Ar substitué par 1 à 4 substituants indépendamment choisis parmi C¿1-6?alkyle, C¿1-6?alcoxy et halo, X est choisi parmi (CH¿2?CH¿2?O)n et (CH)n, et n = 1 à 4. L'invention concerne également des sels, des solvates et des hydrates de ces composés, lesquels sont utiles pour moduler ou inhiber la prolifération cellulaire.
Cimpean Octavian Laurand
Demin Peter
Grunberger Thomas
Roifman Chaim M.
Rounova Olga B.
Gowling Lafleur Henderson Llp
The Hospital For Sick Children
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