Compounds for modulating cell proliferation

Details Compounds for modulating cell proliferation Compounds for modulating cell proliferation

C - Chemistry, Metallurgy

07

C

C07C 255/41 (2006.01) A61K 31/165 (2006.01) A61K 31/216 (2006.01) A61K 31/222 (2006.01) A61K 31/265 (2006.01) A61K 31/277 (2006.01) A61K 31/4402 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) C07C 255/23 (2006.01) C07C 309/67 (2006.01) C07C 309/73 (2006.01) C07C 317/44 (2006.01) C07C 317/46 (2006.01) C07D 213/70 (2006.01)

Patent

CA 2473763

The following compounds of formulae (I) and (III) which may be useful in treating a variety of cell proliferative disorders are disclosed: Fomula (I), (II), wherein R1, R2 and R3 are each independently selected from H, OH, C1- 6alkyl, C1-6 alkoxy, NH2, NH-C1-6alkyl, N(C1-6alkyl)(C1-6 alkyl), SH, S-C1-6 alkyl, NO2, CF3, OCF3 and halo; R4 is unsubstituted Ar, or Ar substituted with 1-4 substituents, independently selected from C1-6alkyl, C1-6 alkoxy and halo; X is selected from (CH2CH2O)n and (CH2)n, and n=1-4.

L'invention concerne des composés représentés par les formules (I) et (III), lesquels peuvent être utiles pour traiter divers troubles de prolifération cellulaire. Dans ces formules (I) et (III), R?1¿, R?2¿, et R?3¿ sont chacun indépendamment choisis dans le groupe comprenant H, OH, C¿1-6?alkyle, C¿1-6?alcoxy, NH¿2?, NH-C¿1-6?alkyle, N(C¿1-6?alkyl)(C¿1-6?alkyl), SH, S-C¿1-6?alkyle, NO¿2?, CF¿3?, OCF¿3? et halo, R?4¿représente Ar non substitué ou Ar substitué avec 1-4 substituants choisis indépendamment dans le groupe comprenant C¿1-6?alkyle, C¿1-6?alcoxy et halo, et X est choisi dans le groupe comprenant (CH¿2?CH¿2?O)¿n?et (CH¿2?)¿n?et n=1-4.

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