C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/09 (2006.01) C07C 217/28 (2006.01) C07C 271/16 (2006.01) C07D 263/14 (2006.01) C07F 9/141 (2006.01) C07F 9/24 (2006.01)
Patent
CA 2611721
The present invention provides methods for preparing TLR-4 receptor agonist E6020 formula(I): and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.
La présente invention concerne des méthodes de préparation d'un agoniste des récepteurs TLR-4, l'E6020 de formule (I), ainsi que des stéréoisomères de celui-ci, lesdits composés étant utiles en tant qu'adjuvants immunologiques lorsqu'ils sont co-administrés avec des antigènes tels que des vaccins contre des maladies bactériennes et virales. L'invention concerne également des intermédiaires de synthèse.
Fang Francis G.
Foy James E.
Hawkins Lynn
Lemelin Charles
Lescarbeau Andre
Eisai Co. Ltd.
Eisai R&d Management Co. Ltd.
Gowling Lafleur Henderson Llp
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