Compounds for reducing aggregation of amyloid beta-peptide

Details Compounds for reducing aggregation of amyloid beta-peptide Compounds for reducing aggregation of amyloid beta-peptide

C - Chemistry, Metallurgy

07

K

C07K 5/02 (2006.01) A61P 25/28 (2006.01) C07C 233/36 (2006.01) C07C 233/47 (2006.01) C07F 9/09 (2006.01)

Patent

CA 2599291

Compounds are disclosed that can inhibit the loss of .alpha.-helical conformation of an A.beta. peptide. Methods of testing such compounds are disclosed as are methods of using the compounds to treat or prevent Alzheimer's disease and related disorders.

L'invention concerne des composés qui inhibent la perte de conformation .alpha.-hélicale d'un peptide A.beta.. Elle concerne également des procédés d'essai de ces composés qui consistent en des procédés d'utilisation des composés en vue de traiter ou de prévenir la maladie d'Alzheimer ainsi que des troubles associés.

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