Compounds for specific viral target

Details Compounds for specific viral target Compounds for specific viral target

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2565658

The present application relates to a compound having a formula (I): B-R1-R2-M wherein B is a binding element for recognizing and binding a target; R1 is a first group of atoms for reacting with a functionality of the target so as to form a covalent bond with the target; R2 is a second group of atoms; R1 and R2 being such that the formation of the covalent bond between R1 and the target generates cleavage of the bond between R1 and R2 so as to free R2-M; and M is selected from the group consisting of a hydrogen atom and a pharmaceutically acceptable moiety. Alternatively, R1 and R2 can be inverted to form the formula II: B-R2-R1-M and being such that the formation of the covalent bond between R1 and the target generates cleavage of the bond between R1 and R2 so as to free R2-B.

La présente invention se rapporte à un composé représenté par la formule (I): B-R1-R2-M, dans laquelle B est un élément de liaison pouvant reconnaître une cible et se lier à celle-ci; R1 est un premier groupe d'atomes pouvant réagir avec un groupe fonctionnel de la cible de manière à former une liaison covalente avec celle-ci; R2 est un second groupe d'atomes; R1 et R2 étant tel que la formation de la liaison covalente entre R1 et la cible provoque un clivage de la liaison entre R1 et R2 aux fins de la libération de R2-M; et M est sélectionné dans le groupe constitué d'un atome d'hydrogène et d'un groupe caractéristique pharmaceutiquement acceptable. Il est également possible que R1 et R2 soient inversés pour former la formule (II): B-R2-R1-M et de sorte que la formation de la liaison covalente entre R1 et la cible provoque le clivage de la liaison entre R1 et R2 aux fins de la libération de R2-B.

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