C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 38/17 (2006.01) A61P 25/28 (2006.01) A61P 27/06 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2666841
The present invention is directed to polypeptides (e.g., fragments) derived from P-glycoprotein and caveolin-1 which are capable of inhibiting the interaction between these two proteins. Inhibition of this interaction leads to increase of efflux of compounds that are transported by P-gp. The invention further includes methods of treating patients having diseases that benefit from increased P-gp-mediated efflux. Such diseases include neoplasms such as cancer and neurological diseases such as neurodegenerative diseases.
La présente invention concerne des polypeptides (par ex. des fragments) dérivés de P-glycoprotéine et de cavéoline-1 qui sont capables d'inhiber l'interaction entre ces deux protéines. L'inhibition de cette interaction conduit à une augmentation du flux de composés qui sont transportés par P-gp. L'invention concerne également des procédés de traitement de patients souffrant de maladies bénéficiant d'un flux induit par P-gp accru. De telles maladies sont par exemple les néoplasmes tels que le cancer et les maladies neurologiques telles que les maladies neurodégénératives.
Barakat Stephane
Beliveau Richard
Demeule Michel
Michaud-Levesque Jonathan
Angiochem Inc.
Goudreau Gage Dubuc
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