A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 35/48 (2006.01) A61K 38/47 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) A61K 45/08 (2006.01) C12N 11/08 (2006.01)
Patent
CA 2171462
Provided is a compound for protecting a vertebrate against infection by helminths comprising hyaluronidase covalently coupled to an immunostimulating carrier, in preferred form, the immunostimulating carrier to which the hyaluronidase is covalently coupled comprising a copolymer of ethylenepiperazine N-oxide and N-ethylacetylethylenepiperazinium bromide (hereafter referred to as "synpol"), and a process for protecting a vertebrate against infection by helminths comprising administration to the vertebrate of a therapeutically effective amount of a compound comprising hyaluronidase covalently coupled to an immunostimulating carrier, preferably synpol, in preferred form, the compound being administered to the vertebrate in the form of a vaccine which includes, in admixture with the compound, synpol, and a process comprising reacting hyaluronidase and an immunostimulating carrier under conditions of time and temperature to covalently couple hyaluronidase and said immunogenic carrier.
Un composé, qui permet de protéger un vertébré contre une infection à helminthes, comprend une hyaluronidase couplée de façon covalente à un vecteur immunostimulant qui, dans sa forme préférée, contient un copolymère d'oxyde N d'éthylènepipérazine et du bromure de N-éthylacétyléthylènepipérazinium (appelé ci-après "synpol"). Un procédé, qui permet de protéger un vertébré contre une infection à helminthes, consiste à lui administrer une quantité thérapeutiquement efficace d'un composé qui comprend de l'hyaluronidase couplée de façon covalente à un vecteur immunostimulant, du synpol de préférence. Ce composé est administré au vertébré sous forme d'un vaccin qui inclut le synpol. Un procédé consiste à faire réagir l'hyaluronidase et un vecteur immunostimulant, dans certaines conditions de durée et de température, pour obtenir le couplage de l'hyaluronidase et de ce vecteur immunogène.
Ataullakhanov Ravshan I.
Daugalieva Emma K.
Khaitov Rakhim M.
Nekrasov Arkady V.
Petrov Rem V.
Npo Petrovax Pharm Llc
Petrovax L.l.c.
Smart & Biggar
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