Compounds for the treatment of dryness of the ocular surface...

A - Human Necessities – 61 – P

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A61P 27/02 (2006.01) A61K 9/08 (2006.01)

Patent

CA 2548446

The invention relates to compounds for the treatment of ocular dryness caused by photorefractive surgery. Agents which block the electric activity of injured nerve endings of the neuroma can be used for the treatment of ocular dryness caused by photorefractive surgery, such as excimer laser photorefractive keractomy or laser-assisted in-situ keratomileusis. The administration of said blocking agents effectively reduces the sensations of ocular dryness, said agents including antiepileptics, anticonvulsants, antiarrhythmics, tricyclic antidepressants and local anaesthetics and, in particular, licodaine, tocainidine, phenytoin, carbamazepine, lamotrigine, mexiletine and pregabaline.

Les agents bloquant l'activité électrique des terminaisons nerveuses lésées du névrome sont utiles pour le traitement de la sécheresse de la surface oculaire provoquée par la chirurgie photoréfractive, comme la photokératectomie réfractive par laser à excimères ou le kératomileusis in situ assisté par laser. L'administration desdits agents bloquants, comprenant des antiépileptiques, des anticonvulsifs, des antiarythmiques, des antidépresseurs tricycliques et des anesthésiques locaux et, plus particulièrement, de la licodaïne, de la tocaïnidine, de la phénitoïne, de la carbamazépine, de la lamotrigine, de la mexiletine et de la pregabaline, réduit efficacement les sensations de sécheresse oculaire.

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