C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/20 (2006.01) A61K 31/365 (2006.01) A61P 3/10 (2006.01) C07D 303/48 (2006.01)
Patent
CA 2637373
Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed, wherein n is 1 or 2; m is 0, 1, 2, 3 or 4; q is 0 or 1; t is 0 or 1; R1 is alkyl having from 1 to3 carbon atoms; R2 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from: halo, hydroxy, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently mono-substituted by methyl or ethyl; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of formula (I) by a ring carbon. Alternatively, the agent can be a pharmaceutically acceptable salt of the compound of formula (I).
L'invention concerne des agents convenant pour le traitement de divers troubles du métabolisme tels que: syndrome de résistance à l'insuline, diabète, syndrome de Stein-Leventhal, hyperlipidémie, stéatose hépatique, cachexie, obésité, athérosclérose ou artériosclérose.(...). Dans cette formule, n vaut 1 ou 2; m vaut 0, 1,2, 3 ou 4; q vaut 0 ou 1; t vaut 0 ou 1; R1est un alkyle comptant de de 1 à 3 atomes de carbone; R2 est hydrogène, halo, alkyle à 1-3 atomes de carbone, ou alkoxy à 1-3 atomes de carbone; A est un phényle non subtitué ou substitué par 1 ou 2 groupes pris parmi: halo, hydroxy, alkyle à 1-2 atomes de carbone, perfluorométhyle, alkoxy à 1-2 atomes de carbone, et pefluorométhoxy, ou un cycloalkyle comptant de trois à 6 atomes de carbone cycliques, le cycloalkyle étant non substitué ou un ou deux carbones cycliques sont indépendamment monosubstitués par méthyle ou éthyle; ou un noyau aromatique à 5 ou 6 élmentscomptant 1 ou 2 hétéroatomes cycliques pris dans N, S et O, ce noyau aromatique est lié par covalence au restant du composé de formule (I) par un carbone cyclique. En variante, l'agent peut être constitué par un sel pharmacompatible du composé de formule (I).
Sharma Shalini
von Borstel Reid W.
Gowling Lafleur Henderson Llp
Wellstat Therapeutics Corporation
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