C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 59/68 (2006.01) A61K 31/192 (2006.01) A61P 3/00 (2006.01) A61P 9/10 (2006.01) C07C 59/90 (2006.01)
Patent
CA 2636290
Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. Formula (I), wherein n is 1 or 2; m is 0, 1, 2, 3, or 4; q is 0 or 1; t is 0 or 1; R1 is hydrogen, halo, hydroxy, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; R2 is alkyl having from 1 to 3 carbon atoms; R3 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; one of R4 and R5 is hydrogen or hydroxy and the other is hydrogen; or R4 and R5 together arc =O; R6 is hydrogen or alkyl having one, two, three, four or five carbon atoms; or a pharmaceutically acceptable salt of the compound. Alternatively, the agent can be a pharmaceutically acceptable salt of the compound of Formula (I).
L'invention concerne des agents convenant pour le traitement de divers troubles du métabolisme tels que: syndrome de résistance à l'insuline, diabète, syndrome de Stein-Leventhal, hyperlipidémie, stéatose hépatique, cachexie, obésité, athérosclérose ou artériosclérose.(...). Ces agents sont représentés par la formule (I) dans laquelle n vaut 1 ou 2; m vaut 0, 1,2, 3 ou 4; q vaut 0 ou 1; t vaut 0 ou 1; R1est hydrogène, halo, hydroxy, alkyle à 1 ou 2 atomes de carbone, et perfluorométhoxy; R2 est un alkyle à 1-3 atomes de carbone, ou un alkoxy à 1-3 atomes de carbone; R3 est hydrogène, halo, alkyle à 1-3 atomes d e carbone ou un alkoxy à 1-3 àtomes de carbone. L'un de R4 et de R5 est hydrogène ou hydroxy, l'autre est hydrogène; ou bien R4 et R5 ensemble = O; R6 est hydrogène ou un alkyle comptant un, deux, trois, quatre ou cinq altomes de carbone; ou bien un sel pharmacocompatible du composé de formule (I).
Sharma Shalini
von Borstel Reid W.
Gowling Lafleur Henderson Llp
Wellstat Therapeutics Corporation
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