Compounds for the treatment of metabolic disorders

Details Compounds for the treatment of metabolic disorders Compounds for the treatment of metabolic disorders

C - Chemistry, Metallurgy

07

C

C07C 59/68 (2006.01) A61K 31/192 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2654530

3-(2,4-Bis(trifluoromethyl)benzyloxy)phenylacetic acid, 4-(2,6-Dimethylbenzyloxy)- phenylacetic acid, and their pharmaceutically acceptable salts are useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis.

La présente invention concerne l'acide 3-(2,4-bis(trifluorométhyl)benzyloxy)phénylacétique, l'acide 4-(2,6-diméthylbenzyloxy)phénylacétique, et leurs sels pharmaceutiquement acceptables. Ces composés se révèlent utiles pour le traitement de divers troubles métaboliques, tels que le syndrome d'insulino-résistance, le diabète, le syndrome des ovaires polykystiques, l'hyperlipidémie, la stéatose hépatique, la cachexie, l'obésité, l'athérosclérose et l'artériosclérose.

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